Is the next blockbuster drug hiding in a century-old venom?

Prialt, a revolutionary painkiller 1,000 times as strong as opiates without the addictive side effects.
Prialt, a revolutionary painkiller 1,000 times as strong as opiates without the addictive side effects.

Aggrastat. Byetta. Captopril. Integrilin. Prialt. What do these drugs have in common? Not what they’re used for, certainly. From angina to diabetes, they treat different diseases or conditions, and all have very different markets. They’re sold by different companies and were discovered in different laboratories around the world. But all have one simple thing in common: they come from animal venoms.

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Sea Stars See!

All men by nature desire to know. An indication of this is the delight we take in our senses; for even apart from their usefulness they are loved for themselves; and above all others the sense of sight” – Aristotle

I see you! A starfish compound eye (red spot). Image credit Dan-Erik Nilsson, Lund University
I see you! A sea star’s compound eye (red spot). Image credit Dan-Eric Nilsson, Lund University

Human beings are very visual animals. We rely on our sight more than any of our other senses to interpret the world around us, which is why over the centuries many have argued (and many still do) that sight is our most important sense. But, of course, we aren’t the only species that can see. Arthropods are particularly known for their acute vision, as are squid, octopus and other cephalopods. Yet although we’ve known about sea star eye spots for hundreds of years, no one knew whether they, too, are able to see images. That is, no one knew until Drs. Anders Garm and Dan-Eric Nilsson decided to investigate.

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Do Stoned Dolphins Give ‘Puff Puff Pass’ A Whole New Meaning?

You would always be smiling, too, if you were high as a kite.
Photo by Flickr user jeffk42

The BBC will be airing a cool new underwater documentary on Thursday called Dolphins: Spy in the Pod, where carefully disguised cameras were used to film the daily lives of everyone’s favorite marine mammals. But the most interesting detail seems to have been leaked on Sunday: during the documentary, some of the dolphins reportedly used a pufferfish to get stoned.

“Even the brightest humans have succumbed to the lure of drugs and, it seems, dolphins are no different,” said The Sunday Times. The article goes on to describe how the team got footage of dolphins gently harassing a pufferfish, which led to the dolphins entering “a trance-like state after apparently getting “high” on the toxin.”

“After chewing the puffer and gently passing it round, they began acting most peculiarly, hanging around with their noses at the surface as if fascinated by their own reflection,” said Rob Pilley, zoologist and one of the producers of the documentary. “This was a case of young dolphins purposefully experimenting with something we know to be intoxicating.” And so it would seem that we can add drug use to the long list of dolphin bad behaviors, (a list which includes bullying, rape and murder, for the record; illicit drug use seems a minor offense in comparison).

It sounds too awesome to be true—which means it probably is.  Continue reading “Do Stoned Dolphins Give ‘Puff Puff Pass’ A Whole New Meaning?”